Destroy All Humans! 2 is a mission-driven alien action game where Crypto works through open areas, swaps between on-foot chaos and saucer destruction, and upgrades a growing tool kit over time. This guide covers the original Destroy All Humans! 2 and the PS2-classic style release, not the later Reprobed remake with different presentation and possible balance differences.
The most important mindset is flexibility. Crypto is not strongest when you force every encounter into a straight shootout. He is strongest when you read the current objective, pick the right mix of weapons, mental powers, disguise tactics, and saucer attacks, then leave before a messy fight wastes health and time. The campaign moves through distinct places such as Bay City, Albion, Takoshima, Tunguska, and the Moon, so each new stop is a chance to learn patrol routes, mission entrances, escape space, and where the saucer can turn a bad ground fight around.
Essential Tips
1. Play the Objective Before the Crowd
The fastest way to lose momentum is to treat every alert as an invitation to clear the whole map. Most missions care about a target, a pickup, a scan, a location, or a scripted threat, not your total enemy count. When the screen gives you a job, move toward that job first and only fight what blocks the route.
That does not mean running blindly. Use cover, streets, alleys, rooftops, or open space to control how many enemies can reach you at once. If the area keeps spawning trouble, finish the step and relocate. Crypto can cause mayhem, but mission progress usually comes from doing the alien job with discipline.
2. Change Tools Instead of Mashing One Weapon
Destroy All Humans! 2 gives Crypto weapons and mental powers because different problems need different answers. A basic enemy group, a vehicle, a guarded approach, and a larger set-piece fight should not all be handled the same way. If a fight feels slow, expensive, or dangerous, the answer is often to switch tools rather than keep firing.
Get comfortable pausing your habits mid-mission. Use direct weapons when you need quick damage, powers when you need control or utility, and the saucer when the fight has grown beyond what Crypto should handle on foot. A favorite weapon is useful, but a full kit is safer.
3. Upgrade Through Pox Mart Regularly
Pox Mart is where collected Furotech Cells turn into stronger weapons and powers. Visit it whenever your supply has built up, especially after completing missions or exploring a new area. Hoarding upgrades makes the next mission harder for no benefit unless you are saving for a specific improvement you already know you want.
For a first playthrough, favor upgrades that make your most reliable tools easier to use under pressure. More damage, wider control, better efficiency, or stronger crowd handling can all matter. Avoid spreading upgrades so thin that nothing feels improved. Pick a few dependable tools and keep them competitive.
4. Use Mental Powers to Lower the Pressure
Crypto’s powers are not side tricks. They help you solve problems before a normal firefight gets out of hand. If guards, civilians, vehicles, or mission targets are making an area chaotic, look for a power-based answer before you burn through health in a long brawl.
Psychokinetic-style control is especially useful when enemies cluster or when a target needs to be moved, disrupted, or kept away. Scan and infiltration options also help you keep mission flow under control. The game is more manageable when you treat powers as your first plan, not your emergency plan.
5. Respect Disguise and Infiltration Moments
Some situations are better handled quietly. If a mission gives you room to approach without immediately starting a war, take that room. Disguise-style play can let you cross guarded spaces, reach the next prompt, or set up an objective before the whole area turns hostile.
When stealth fails, do not panic and stand in the center of the alert. Break line of sight, move around corners, and turn the failed approach into a controlled fight. A messy entry can still become a clean mission if you keep moving and avoid letting every enemy attack from every angle.
6. Bring in the Saucer When the Scale Changes
The saucer is part of the main kit, not a novelty. When objectives escalate into vehicle destruction, base pressure, or large-area fights, fighting on foot can become inefficient. If the mission points you toward saucer use, trust that shift and think bigger.
In saucer sections, keep moving and avoid hovering like a stationary target. Sweep through attack lanes, line up shots, and reposition before incoming fire surrounds you. The saucer can clear threats quickly, but it still rewards awareness and spacing.
7. Learn Each Hub Before Rushing the Next Marker
Every new area has its own layout, patrol rhythm, landmarks, and mission entrances. Spend a little time learning how streets connect, where open spaces give you room to fight, and where tight paths can trap you. This is not just sightseeing; it makes later mission restarts and escapes much easier.
Use early, lower-pressure moments in each hub to test movement and tool timing. If you know the area, an alarm becomes a detour instead of a disaster. If you do not know the area, even simple objectives can feel more dangerous than they are.
8. Keep Heavy Tools for Heavy Problems
It is tempting to use the loudest option on every enemy, but stronger attacks are most valuable when the mission throws something sturdier at you. Smaller threats can often be handled with cheaper weapons, powers, movement, or a quick objective push.
Before a big encounter, check whether your preferred tools are upgraded and whether you have enough room to use them. A heavy weapon used at the wrong range can leave you exposed, while a power used at the right moment can give you the space to finish the job cleanly.
9. Treat Optional Exploration as Upgrade Fuel
Exploration is useful when it makes Crypto stronger or helps you understand the map. If you are wandering only to start random fights, you are probably wasting time. Look for rewards, routes, and useful landmarks, then turn that knowledge into better mission play.
Furotech Cells are the main reason to poke around outside the direct objective path. When exploration pays out, bank that value at Pox Mart instead of drifting into another unscripted battle. The best detours are the ones that improve the next required mission.
10. Separate Original Habits From Remake Habits
Players coming from Destroy All Humans! 2 - Reprobed should be careful. The original game has the same broad alien fantasy, but presentation, feel, interface, and tuning may not line up perfectly with the remake. Use this guide for original-era play and test any remake habit before trusting it here.
The reverse is also true. If you later play Reprobed, do not assume every exact route, timing, or upgrade priority from the original is still best. Keep the general lessons: follow objectives, upgrade regularly, use powers, and bring the saucer when the fight gets too large.
Common Mistakes to Avoid
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Do not fight every enemy just because they are nearby - Push the active objective first, then clear only the threats that stop progress.
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Do not ignore Pox Mart after collecting Furotech Cells - Upgrades make weapons and powers more reliable before difficulty spikes.
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Do not use one favorite weapon for every situation - Switch between damage, control, infiltration, and saucer tools as the mission changes.
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Do not treat powers like optional jokes - Mental abilities can reduce pressure before a fight becomes a health drain.
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Do not start alarms when a quiet approach is available - Disguise and infiltration moments can save time and keep enemies manageable.
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Do not stay on foot when the mission clearly needs the saucer - Large targets and area fights are often built for bigger firepower.
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Do not hover in one place during saucer combat - Keep moving, line up attacks, and reposition before return fire stacks up.
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Do not spend every detour on random chaos - Explore for upgrades, routes, and map knowledge that help the campaign.
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Do not assume Reprobed details always match the original - Treat remake habits as separate until you confirm them in the version you are playing.
Summary
| Category | Top Tip |
|---|---|
| Missions | Follow the active objective before chasing every enemy |
| Combat | Switch tools when a fight feels slow or dangerous |
| Upgrades | Spend Furotech Cells at Pox Mart regularly |
| Powers | Use mental abilities to control pressure early |
| Infiltration | Take quiet routes when the mission allows them |
| Saucer | Use it when battles scale beyond on-foot combat |
| Exploration | Learn hubs and collect upgrade fuel between missions |
| Version Scope | Keep original and Reprobed habits separate |
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5 checked for this guideEvery factual claim in this guide was checked against at least two independent sources before publication. These are the references used for Destroy All Humans! 2.
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